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Lived experiences and quality of life in people with severe, biologic-treated chronic rhinosinusitis with nasal polyps: a hermeneutic phenomenological study

PubMed (Clinical Literature) Nov 1, 2026

CONCLUSIONS: People with severe, biologic-treated CRSwNP experience communication and sleep difficulties, impaired sex life, discrimination and self-medication, which substantially deteriorates their quality of life. This is compounded by diagnostic uncertainty, the need for self-management, treatment…

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Nasal symptoms are independently associated with subjective sleep impairment and symptom awareness in obstructive sleep apnea: an otolaryngology-based cohort study

PubMed (Clinical Literature) Nov 1, 2026

CONCLUSIONS: Nasal symptoms are independently associated with subjective sleep impairment in OSA beyond polysomnography-defined severity. Daytime rhinomanometry does not reflect nasal symptoms or sleep quality. Most patients with severe OSA lacked perceived impairment; nasal symptom…

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Sleep architecture disruption and coordinated patterns of inflammatory and extracellular matrix biomarkers in obstructive sleep apnea: a cross-sectional study

PubMed (Clinical Literature) Nov 1, 2026

CONCLUSION: OSA severity is associated with coordinated patterns among inflammatory and ECM-related biomarkers that parallel hypoxic burden and sleep architecture changes. In contrast, systemic oxidative stress markers appear less integrated within these patterns. These findings…

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Esketamine as a Perineural Adjuvant to Ropivacaine for Pericapsular Nerve Group (PENG) Block in Elderly Patients Undergoing Hip Fracture Surgery: A Propensity Score-Matched Retrospective Cohort Study

PubMed (Clinical Literature) Nov 1, 2026

CONCLUSION: Among elderly patients undergoing hip fracture surgery, esketamine added to ropivacaine for PENG block improved 24-hour recovery quality (QoR-15, exceeding MCID; 48-hour scores higher but below MCID), prolonged sensory block, shortened time to first…

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Effect of Adding Esketamine to Patient-Controlled Intravenous Analgesia on Rebound Pain After Interscalene Brachial Plexus Block: A Randomized Controlled Trial

PubMed (Clinical Literature) Nov 1, 2026

CONCLUSION: Adding esketamine to postoperative PCIA did not demonstrate a reduction in rebound pain incidence after interscalene brachial plexus block. Exploratory subgroup findings suggested lower rebound pain intensity and duration, while improvements in postoperative analgesia,…

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Effect of Preoperative Intranasal Dexmedetomidine on Postoperative Myocardial Injury in Patients Undergoing Coronary Artery Bypass Grafting

PubMed (Clinical Literature) Nov 1, 2026

CONCLUSION: In this single-center trial, two-dose preoperative intranasal dexmedetomidine was associated with lower postoperative hs-cTnT and CK-MB concentrations, better subjective preoperative sleep quality, and a lower observed incidence of postoperative delirium. These findings are preliminary…

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