Today’s Sleep Headlines …
Progesterone in feminizing gender affirming hormone therapy: study protocol for a randomized placebo-controlled trial
BACKGROUND: Transgender women receiving feminizing hormone therapy increasingly request progesterone based on anecdotal reports of improved breast development, sleep, mood, and quality of life. However, evidence supporting progesterone as an adjunct to feminizing gender-affirming hormone…
Read full source →The implications of circadian rhythms for anaesthesia
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Read full source →Evolving Concepts in the Diagnosis and Management of Fibromyalgia: A Moving Target
Fibromyalgia (FM) is a chronic, multifactorial pain syndrome involving widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive dysfunction, significantly reducing the quality of life of patients. FM is classified under MG30.01, representing chronic widespread pain,…
Read full source →Public Awareness and Recognition of Alarming Symptoms of Post-traumatic Intracranial Hemorrhage: A Cross-Sectional Study
CONCLUSIONS: There is moderate awareness regarding certain symptoms such as altered levels of consciousness and convulsions. However, notable gaps persist in awareness of several risk factors and child-specific symptoms, including changes in feeding habits, alterations…
Read full source →Genome-wide association study of restless legs syndrome in end-stage renal disease
CONCLUSIONS: Our findings indicate that uRLS and iRLS share a substantial part of their genetic architecture, while also pointing to candidate signals specific to uRLS.
Read full source →Stress and Sleep in Adolescence: The Interactive Effects of Skin Conductance Level Reactivity and Parental Psychological Control
Adolescents are vulnerable to poor sleep, and both individual and environmental factors predict youth sleep problems. The present study examined the independent and interactive associations of adolescent sympathetic nervous system reactivity and experiences of parenting…
Read full source →Network Analysis of Anxiety and Depression Symptoms in Help-Seeking Youth: A Two-Wave Study
AIM: Anxiety and depression often co-occur in youth, but the symptom-level processes driving this comorbidity remain unclear. Network theory conceptualizes mental disorders as systems of interacting symptoms. We applied a two-wave longitudinal network approach to…
Read full source →Depressive Symptoms, sleep Disturbance, and Cardiometabolic Multimorbidity Among Adults With Arthritis: A Cross-Sectional Analysis of NHANES 2013-2020
While the association between depressive symptoms and cardiometabolic disease is well established, the relationships among depressive symptoms, sleep disturbance, and cardiometabolic multimorbidity (CMM) in adults with arthritis remain insufficiently understood. This cross-sectional study used National…
Read full source →Substance use to cope with trauma: the interactive effect of insomnia and neighborhood socioeconomic status
CONCLUSIONS: Living in less disadvantaged areas exacerbated the prospective effect of insomnia on risk for substance use to cope after trauma. Trauma patients with insomnia may benefit from sleep-focused interventions that consider alternative coping strategies…
Read full source →Banxia Shumi Decoction Alleviates PCPA-Induced Insomnia and Regulates ADAM10 Expression via Melatonin Signaling in Rats
CONCLUSION: BXSMD effectively alleviates PCPA-induced insomnia in rats. The mechanism relies on MT1/MT2 as core targets, which mediate the regulation of sleep-related molecules (CLOCK, PER1, CaMKII, p-CREB/CREB, GABARAP, and mGluR1), as well as the membrane…
Read full source →Sex Differences in the Prevalence and Correlates of Sleep Disturbance Among Indonesian Stroke Survivors: A Population-Based Study of 7,147 Individuals
CONCLUSIONS: This study's findings revealed a significant prevalence of sleep disturbance among stroke survivors in Indonesia. Our findings indicate a gender influence on sleep disturbance prevalence, with females exhibiting a higher prevalence than males. These…
Read full source →Shank3 mutation disrupts the molecular signature of sleepiness across development
CONCLUSIONS: The Shank3 ^(ΔC) mutation impairs the molecular accumulation of and response to sleepiness, both by elevating oxidative stress responses and by blocking the age-typical upregulation of pathways that differ between juveniles and adults.
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