Jet Lag Disorder

Def: temporary misalignment between body clock and destination solar/sleep-wake cycleTypically after trans-meridian travel across ≥3 time zones Direction of travelUsually worse with eastward travel, needs phase advancePhase advance harder to achieve than phase delay (westward)80% of people have intrinsic circadian period >24 hrs, constantly delaying slightlyMakes eastward phase advance harder and slowerClock typically resets ~1… Continue reading →

Shift Work Disorder (SWD)

Def: insomnia and excessive sleepiness from work hours that overlap usual sleep timeMore common with night, early or rotating shifts than late or split shiftsPrevalence up to 38% in rotating shift workers Health and safety concernsSafety risk: occupational accidents, professional driversHigher rates of mental and physical health problemsEpidemiological links to metabolic and CV dzReports of… Continue reading →

Irregular Sleep-Wake Rhythm Disorder

Def: no clearly defined sleep-wake cycle, disorganized sleep and wake spread across 24 hrsMultiple (usually >3) short, arrhythmic sleep episodes of varying length (usually <4 hrs)ICSD-3: sx ≥3 months, diary or actigraphy ≥7 days (ideally 14) showing ≥3 sleep bouts/24 hrs Associated conditionsUsually coexists with another condition PathophysiologyBiological: disruption of circadian pathwaysEnvironmental: weak daylight exposure… Continue reading →

Non-24-Hour Sleep-Wake Rhythm Disorder

Def: sleep-wake cycle desynchronized from the solar cyclePeriod length typically >24 hrsSleep onset delays progressively, usually 20-60+ min per dayICSD-3: sx ≥3 months, diary or actigraphy ≥14 days showing daily delay EpidemiologySeen in blind (esp no light perception) and sighted pts≥50% of totally blind individuals may have Non-24 Associated conditions PathophysiologyTotally blind: no photic entrainment,… Continue reading →

Advanced Sleep-Wake Phase Disorder

Def: chronic (>3 months) major advance (>2-3 hrs) in sleep-wake timing vs desired or required scheduleMain sx: early morning (terminal) insomnia EpidemiologyPrevalence <1%, possibly underreported since less disruptive than DSWPDMore common in older adultsRare autosomal dominant familial forms with PER2 and CSNK1D mutationsAssoc with neurodevelopmental d/o: Smith-Magenis syndrome, ASD, chromosomal microdeletions PathophysiologyInverse of DSWPD mechanismsExcess… Continue reading →

Delayed Sleep-Wake Phase Disorder

Def: chronic (>3 months) major delay (>2-3 hrs) in sleep-wake timing vs desired or required schedulePrevalence 1-10%More common in teens and young adults, can start in childhoodFamily hx common (up to 40%) Consequences of social schedule:1. Sleep onset insomnia2. Difficulty waking at acceptable time, may cause sleep inertia (sleep drunkenness)3. Chronic sleep restriction4. EDS, esp… Continue reading →

Your Home Sleep Test Was Normal but You Still Feel Exhausted: Why Home Sleep Studies Can Miss Sleep Apnea and What to Do Next

A normal home sleep test result feels like good news. For many people, it is accurate. But a home sleep apnea test can miss sleep apnea, and research shows this happens more often than most people expect. If you still snore loudly, wake up gasping, or feel tired no matter how long you sleep, a… Continue reading →